Thermo Fisher Scientific CD210 (IL-10R) Monoclonal Antibody (1B1.3a), Functional Grade, eBioscience

Applications

Flow Cytometry (Flow)

• Tested Dilution: -
• View 2 publications

Functional Assay (Functional)

• Tested Dilution: Assay-Dependent
• View 2 publications

Product Specifications

Product Specific Information

Description:
The 1B1.3A monoclonal antibody reacts with mouse CD210 (IL-10 receptor), a member of the interferon receptor-like family expressed on thymocytes, T cells, B cells, NK cells, monocytes, and macrophages. Binding of IL-10 to its receptor initiates JAK/STAT signaling that promotes B cell proliferation and inhibits macrophage activation.

The 1B1.3A antibody has been reported to have neutralizing activity.

Applications Reported:
The 1B1.3A antibody has been reported for use in functional assays.

Storage and Handling:
Use in a sterile environment.

Filtration:
0.2 µm post-manufacturing filtered.

Purity:
Greater than 90%, as determined by SDS-PAGE.

Endotoxin Level:
Less than 0.001 ng/µg antibody, as determined by LAL assay.

Aggregation:
Less than 10%, as determined by HPLC.

Target Information

The protein encoded by this gene is a receptor for interleukin 10, structurally related to interferon receptors. It mediates the immunosuppressive signal of IL-10, inhibiting synthesis of proinflammatory cytokines. This receptor promotes survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and one non-coding, have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.