Thermo Fisher Scientific CD209b (SIGN-R1) Monoclonal Antibody (eBio22D1 (22D1)), Functional Grade, eBioscience
마우스 SIGNR1(CD209b)을 특이적으로 인식하는 Armenian hamster 유래 단클론 항체로, Flow cytometry, IHC, ELISA 등 다양한 면역분석에 적합. 고순도(>90%) 및 저엔도톡신(<0.001 ng/µg) 보장. 4°C에서 보관하며, 기능적 등급으로 in vivo 실험에도 활용 가능.
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Thermo Fisher Scientific CD209b (SIGN-R1) Monoclonal Antibody (eBio22D1 (22D1)), Functional Grade, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 2 publications |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | View publications |
| Flow Cytometry (Flow) | 0.5 µg/test | View 2 publications |
| ELISA | Assay-Dependent | View publications |
| Immunoprecipitation (IP) | Assay-Dependent | View publications |
| Functional Assay | Assay-Dependent | View publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published Species | Mouse |
| Host / Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), Functional Grade, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio22D1 (22D1) |
| Conjugate | Functional Grade |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2865923 |
Available Formats:
Product Specific Information
The eBio22D1 monoclonal antibody reacts with mouse SIGNR1 (CD209b), a type II transmembrane C-type lectin identified as a mouse homologue of human DC-SIGN. SIGNR1 is highly expressed in splenic marginal zone macrophages and lymph node medullary macrophages, functioning in uptake of dextran polysaccharides and Streptococcus pneumoniae capsular polysaccharides. SIGNR1 associates with TLR4/MD2, suggesting a role in LPS recognition. SIGNR1-deficient mice show defects in complement component C3 catabolism, and SIGNR1 binds complement subcomponent C1q to form a non-conventional C3 convertase.
The eBio22D1 antibody does not cross-react with SIGNR2, SIGNR3, or SIGNR4.
Applications Reported:
- Flow cytometry
- Immunoprecipitation
- Immunohistology (frozen tissue)
- ELISA
- In vivo injection induces temporary SIGNR1 knockdown
Applications Tested:
- Flow cytometric analysis of mouse splenocytes
Recommended ≤ 0.5 µg per test (defined as staining 10⁵–10⁸ cells in 100 µL).
Optimize dilution for best performance.
Storage and Handling:
- Use in sterile environment
- 0.2 µm post-manufacturing filtered
- Purity: >90% (SDS-PAGE)
- Endotoxin: <0.001 ng/µg (LAL assay)
- Aggregation: <10% (HPLC)
Target Information
SIGNR1 is a type II transmembrane C-type lectin expressed in macrophages of spleen and lymph node, mediating uptake of polysaccharides and interacting with TLR4/MD2 in LPS recognition. SIGNR1 binds complement C1q to assemble a non-conventional C3 convertase, and its deficiency leads to defects in complement catabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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