Thermo Fisher Scientific MUC1 Monoclonal Antibody (MH1 (CT2))
MUC1 단백질을 인식하는 Armenian hamster 유래 단클론 항체로, 인간 및 마우스 시료에 반응합니다. Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용에 적합하며, Breast cancer 연구에 유용합니다. 단백질 G 정제, PBS/BSA buffer에 보관됩니다.
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Thermo Fisher Scientific MUC1 Monoclonal Antibody (MH1 (CT2))
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:50 | 21 |
| Immunohistochemistry (IHC) | - | 19 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 | 4 |
| Immunohistochemistry (Frozen) (IHC (F)) | - | 1 |
| Immunocytochemistry (ICC/IF) | 1:10–1:100 | 12 |
| Flow Cytometry (Flow) | 1–2 µg/test | - |
| Immunoprecipitation (IP) | - | 8 |
| ChIP assay (ChIP) | - | 7 |
| Miscellaneous PubMed (Misc) | - | 4 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Armenian hamster / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MH1 (CT2) |
| Immunogen | Synthetic peptide corresponding to aa 239–255 (SSLSYTNPAVAATSANL) from the cytoplasmic tail of MUC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11000874 |
Product Specific Information
- MA5-11202 detects smaller subunits (14–28 kDa) of MUC1.
- MUC1 is overexpressed in breast cancer cells.
- T47D cell lysate can be used as a positive control.
Target Information
MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM and EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages.
It is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through several intermediate forms generated by proteolysis and sequential addition and processing of numerous O-linked glycans that are heavily sialylated.
MUC1 is highly polymorphic, with alleles encoding products containing 30–90 repeats, leading to large differences in molecular weight.
It is expressed abundantly in >90% of breast carcinomas and metastases.
Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
Overexpression, aberrant intracellular localization, and changes in glycosylation of MUC1 are associated with carcinomas.
Multiple alternatively spliced transcript variants exist, encoding different isoforms of MUC1, though only some full-length forms have been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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