Thermo Fisher Scientific MUC1 Monoclonal Antibody (MH1 (CT2))

Thermo Fisher Scientific MUC1 Monoclonal Antibody (MH1 (CT2))

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• MA5-11202 detects smaller subunits (14–28 kDa) of MUC1.
• MUC1 is overexpressed in breast cancer cells.
• T47D cell lysate can be used as a positive control.

Target Information

MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM and EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages.
It is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through several intermediate forms generated by proteolysis and sequential addition and processing of numerous O-linked glycans that are heavily sialylated.
MUC1 is highly polymorphic, with alleles encoding products containing 30–90 repeats, leading to large differences in molecular weight.
It is expressed abundantly in >90% of breast carcinomas and metastases.
Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
Overexpression, aberrant intracellular localization, and changes in glycosylation of MUC1 are associated with carcinomas.
Multiple alternatively spliced transcript variants exist, encoding different isoforms of MUC1, though only some full-length forms have been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.