Thermo Fisher Scientific Phospho-Ataxin 3 (Ser256) Polyclonal Antibody
Ataxin 3 단백질의 Ser256 인산화 형태를 인식하는 Rabbit Polyclonal 항체. Western blot과 IHC(Paraffin) 실험에 적합. Human, Mouse, Rat 반응성. 1 mg/mL 농도의 액상 형태로, PBS(glycerol 포함) 용액에 보존. 연구용으로만 사용 가능.
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- PA5105967
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ATXN3 (Accession P54252), corresponding to amino acid residues around phosphorylated Ser256. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817366 |
Product Specific Information
This antibody detects endogenous levels of Ataxin 3 only when phosphorylated at Ser256.
Target Information
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder caused by expansion of (CAG)n repeats in the Ataxin-3 gene. The MJD protein interacts with transcriptional regulators (CBP, p300, PCAF) and functions as a histone-binding and deubiquitinating enzyme. The number of CAG repeats inversely correlates with disease onset age.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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