Thermo Fisher Scientific Phospho-Bim (Thr56, Thr116) Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000–1:3,000 dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of Bim only when phosphorylated at Thr116 (Isoform BimEL, O43521-1) or Thr56 (Isoform BimL, O43521-2).

Target Information

BIM belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in diverse cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3) and interacts with other BCL-2 family members such as BCL2, BCL2L1/BCL-X(L), and MCL1, functioning as an apoptotic activator. Expression can be induced by nerve growth factor (NGF) and the forkhead transcription factor FKHR-L1, suggesting roles in neuronal and lymphocyte apoptosis. Mouse transgenic studies indicate this gene is an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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