Thermo Fisher Scientific SERPINC1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Dilution: 1:25,000–1:50,000

Immunoprecipitation (IP)

• Tested Dilution: 0.1–0.5 µL/mg of lysate

Product Specifications

Target Information

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. It inhibits thrombin and other activated serine proteases of the coagulation system, regulating the blood coagulation cascade.
This protein includes two functional domains:

• Heparin binding-domain at the N-terminus
• Reactive site domain at the C-terminus

The inhibitory activity is enhanced by the presence of heparin.
More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.