Thermo Fisher Scientific SEPT2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human SEPT2 for WB and IP applications. Recognizes filament-forming cytoskeletal GTPase involved in actin organization and mitosis. Supplied as a liquid, unconjugated form, stored at -20°C. For research use only.
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- PA5118255
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 1–5 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human SEPT2 fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902854 |
Target Information
Septin 2 is a filament-forming cytoskeletal GTPase required for proper organization of the actin cytoskeleton. It plays a crucial role in the formation of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, facilitating efficient vesicle transport, and preventing MAP4 binding to tubulin. Septin 2 is also essential for mitotic progression, forming a scaffold at the midplane of the mitotic spindle to maintain CENPE localization at kinetochores, aiding chromosome congression. During anaphase, it contributes to chromosome segregation and spindle elongation. Additionally, Septin 2 is involved in ciliogenesis and collective cell movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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