Thermo Fisher Scientific DNAJC13 Polyclonal Antibody
DNAJC13 단백질을 인식하는 Thermo Fisher의 Rabbit Polyclonal Antibody로, WB 및 IHC(P)에서 사용 가능. 인간 및 생쥐 반응성, 항원 친화 크로마토그래피로 정제됨. 액상 형태, 1 mg/mL 농도, 냉장 또는 냉동 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 18 amino acid peptide near the carboxy terminus of human DNAJC13 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at –20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2554630 |
Product Specific Information
- Recommended positive control: human heart tissue lysate
- Detects both known isoforms of DNAJC13
- Not expected to cross-react with other DNAJC family members
Target Information
DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog of a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans.
It functions as a co-chaperone of Hsc70, regulating protein conformation at membrane sites and playing a role in intracellular trafficking.
DNAJC13 co-localizes with endosomal system markers and is involved in membrane trafficking through early endosomes but not degradative organelles.
It also regulates intracellular trafficking of the epidermal growth factor receptor (EGFR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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