Thermo Fisher Scientific CD48 Monoclonal Antibody (HM48-1), APC, eBioscience
마우스 CD48 항원 인식용 HM48-1 단클론 항체로, APC 형광체 결합 제품입니다. Flow cytometry에 최적화되어 있으며 0.125 µg/test로 사용됩니다. 적혈구 및 면역세포 표면 CD48 분석에 적합하며, 4°C 암조건에서 보관합니다.
- 카탈로그번호
- 17-0481-8x (2개 옵션)
- 판매단위
- pk
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Thermo Fisher Scientific CD48 Monoclonal Antibody (HM48-1), APC, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 0.125 µg/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HM48-1 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_469407 |
Available Formats
- Alexa Fluor 700
- APC-eFluor 780
- Biotin
- eFluor 450
- FITC
- NovaFluor Blue 660-120S
- NovaFluor Blue 690
- NovaFluor Red 685
- NovaFluor Red 725
- NovaFluor Red 755
- NovaFluor Yellow 610
- NovaFluor Yellow 700
- NovaFluor Yellow 730
- NovaFluor Yellow 755
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 600
- Super Bright 702
- Request custom conjugation
Product Specific Information
The HM48-1 monoclonal antibody reacts with the mouse CD48 antigen, also known as BCM1, Blast-1 (human), and OX-45 (rat). CD48 is a 45 kDa GPI-linked glycoprotein expressed on most hematopoietic cells and plays a critical role in adhesion and T cell activation.
Members of the SLAM family, including CD48, CD150, and CD244, show differential expression among hematopoietic progenitors, providing a useful tool for stem cell characterization:
- HSCs: CD150(+)CD244(-)CD48(-)
- MPP: CD244(+)CD150(-)CD48(-)
- Restricted progenitors: CD48(+)CD244(+)CD150(-)
HM48-1 modulates CD48 functions in vitro and in vivo, including blocking CD48/CD2 and CD48/CD244 interactions, inhibiting spleen cell proliferation, providing costimulation for TCR-activated T cells, and prolonging cardiac allograft survival.
Applications Reported: Flow cytometric analysis
Applications Tested: Mouse splenocytes, ≤ 0.125 µg/test (100 µL final volume, 10⁵–10⁸ cells/test)
Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD48 (Blast-1) belongs to the CD2 subset of the Ig superfamily, including CD2, CD58, CD84, CD150, CD229, and CD244. It is a GPI-anchored protein broadly expressed on hematopoietic cells and serves as a ligand for 2B4 and CD2.
Functions and expression:
- Strongly expressed on lymphocytes and monocytes
- Weakly on granulocytes
- Absent on platelets, fibroblasts, epithelium, and endothelium
- Marker for detecting GPI anchoring defects in PNH patients
- Involved in allergic airway disease pathology and potential therapeutic target for rhinitis and asthma
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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