Thermo Fisher Scientific CTDSPL Polyclonal Antibody
Human CTDSPL 단백질을 인식하는 Rabbit Polyclonal 항체. IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제. PBS, 40% 글리세롤, 0.02% sodium azide 함유. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CTDSPL. Recombinant protein control fragment (Product #RP-100963). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640224 |
Product Specific Information
Immunogen sequence:
AIITQVTNPK EDEGRLPGAG EKASQCNVSL KKQRSRSILS SFFCCFRDYN VEAPPPSSPS VLPPLVEENG GLQKGDQ
Highest antigen sequence identity to the following orthologs:
- Mouse: 90%
- Rat: 41%
Target Information
Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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