Thermo Fisher Scientific CTDSPL Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:2,500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CTDSPL. Recombinant protein control fragment (Product #RP-100963). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CTDSPL,uniProtId:O15194-1,ncbiNodeId:9606,antigenRange:5-81,antigenLength:276,antigenImageFileName:PA5-61713_CTDSPL_O15194-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61713_CTDSPL_O15194-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640224

Product Specific Information

Immunogen sequence: AIITQVTNPK EDEGRLPGAG EKASQCNVSL KKQRSRSILS SFFCCFRDYN VEAPPPSSPS VLPPLVEENG GLQKGDQ

Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 41%.

Target Information

Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.