Thermo Fisher Scientific Connexin 46 Polyclonal Antibody
Human Connexin 46 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%)를 유지합니다. 렌즈 세포 간 결합 연구 및 Cx46 관련 단백질 분석에 활용됩니다.
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Thermo Fisher Scientific Connexin 46 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Publications: - [참고 문헌 없음]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human Connexin 46 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2719611 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Connexin 46 (Cx46), also known as Gap Junction Protein Alpha-3 (GJA3), CAE3, CX46, and C2P3, maps to human chromosome 13q11–q12 and encodes a 46 kDa protein.
Cx46, along with Cx50, is primarily expressed in the lens of the eye. It mediates intercellular interactions during development and is necessary for neural crest cell survival.
Cx46 forms gap junctions that connect lens fiber cells, crucial for maintaining lens transparency and normal lens function. Mutations in Cx46 result in severe cataracts.
Knockouts of Cx46 and Cx50 alter lens fiber cell differentiation and cell size, indicating that their interaction is essential for proper fiber cell organization.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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