Thermo Fisher Scientific Phospho-B Raf (Thr599) Polyclonal Antibody
인간 B-Raf Thr599 인산화 부위를 인식하는 폴리클로날 항체로, IHC, ICC/IF, ELISA 등 다양한 응용에 적합. Rabbit IgG 기반, Protein A 정제, 고농도(1 mg/mL) 액상 형태. MAPK/ERK 신호전달 연구 및 암 관련 단백질 분석에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human B-Raf around the phosphorylation site of Thr599 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
BRAF is involved in transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutations in human cancer and plays a role in postsynaptic responses of hippocampal neurons. This protein regulates the MAP kinase/ERK signaling pathway, influencing cell division, differentiation, and secretion. Mutations in B-Raf are associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and lung adenocarcinoma. A pseudogene located on chromosome X has been identified for B-Raf.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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