Thermo Fisher Scientific TLE5/Amino-terminal enhancer of split Polyclonal Antibody
인간, 마우스, 랫트에 반응하는 TLE5/AES 폴리클로날 항체로, 다양한 면역염색(IHC, ICC, ELISA)에 사용 가능. KLH 결합 합성 펩타이드로부터 유래하며, Protein A로 정제된 고순도 항체. 세포 부착 및 아노이키스 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human TLE5/Amino-terminal enhancer of split, amino acids 21–120 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Adhesion to the extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apoptosis induced by integrin detachment.
Amino-terminal enhancer of split (AES) is a member of the Groucho/transducin-like enhancer of split (TLE) family of transcriptional regulators, which act as co-repressors involved in neurogenesis, segmentation, and sex determination.
AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein released into the cytoplasm upon apoptosis initiation. This complex is thought to suppress survival-promoting gene transcription controlled by the TLE family. Interestingly, apoptosis of cells transfected with AES and Bit1 can be inhibited when cells attach to fibronectin through the α5β1 integrin, suggesting that the Bit1–AES pathway contributing to anoikis is integrin-regulated, particularly via α5β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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