Thermo Fisher Scientific PDCD4 Recombinant Rabbit Monoclonal Antibody (3A8V10)
PDCD4 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ELISA 등에 사용 가능. 사람, 생쥐, 랫트 반응성. 액상 형태로 -20°C 보관. 세포자멸사 관련 연구 및 종양 억제 단백질 분석에 적합.
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Thermo Fisher Scientific PDCD4 Recombinant Rabbit Monoclonal Antibody (3A8V10)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3A8V10 |
| Immunogen | A synthetic peptide corresponding to amino acids 370–469 of human PDCD4 (Q53EL6) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.33 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2912047 |
Product Specific Information
Positive test controls include HeLa, 293T, U-937, Mouse liver, and Mouse thymus.
Target localization: Cytoplasm, Nucleus.
Immunogen sequence:
MVLESTGEST FKMILDLLKS LWKSSTITVD QMKRGYERIY NEIPDINLDV PHSYSVLERF VEECFQAGII SKQLRDLCPS RGRKRFVSEG DGGRLKPESY
Target Information
PDCD4 (Programmed Cell Death Protein 4) is a tumor suppressor protein involved in apoptosis and cell growth regulation. Its expression increases during apoptosis and is often lost in carcinomas of breast, colon, lung, and prostate. PDCD4 inhibits the helicase activity of eIF4A and the transactivation mediated by AP-1. Akt kinase phosphorylates PDCD4, reducing its inhibitory effect on AP-1-responsive promoters. Two isoforms of PDCD4 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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