Thermo Fisher Scientific Periostin Recombinant Rabbit Monoclonal Antibody (7S3E5)
Human Periostin 단백질을 인식하는 recombinant rabbit monoclonal antibody로, Western blot 및 ELISA에 적합합니다. HEK293 세포에서 발현되었으며, 고순도의 affinity chromatography 정제 제품입니다. 안정적인 액상 형태로 장기 보관에 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7S3E5 |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human Periostin (NP_001129406.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.35 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3) with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2912044 |
Product Specific Information
- Positive test controls: MCF7
- Immunogen sequence:
MIPFLPMFSL LLLLIVNPIN ANNHYDKILA HSRIRGRDQG PNVCALQQIL GTKKKYFSTC KNWYKKSICG QKTTVLYECC PGYMRMEGMK GCPAVLPIDH
Target Information
Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a disulfide-linked protein originally identified as an osteoblast-specific factor.
It is a secreted protein that binds heparin and functions as a ligand for integrins αVβ3 and αVβ5. In preosteoblasts, Periostin acts as a cell adhesion molecule involved in osteoblast recruitment, spreading, and attachment.
Periostin is mainly found in the lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues, and is upregulated in epithelial ovarian tumors and breast cancer.
Its expression is increased by BMP2 and TGF-β1. Periostin contains a signal sequence, a cysteine-rich domain, four fasciclin-like repeats, and a C-terminal domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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