Thermo Fisher Scientific PKP2 Polyclonal Antibody
Rabbit polyclonal antibody against human PKP2, validated for IHC and ICC/IF applications. Antigen affinity purified, supplied as liquid in PBS with 40% glycerol. Suitable for research use in desmosome and cardiac morphology studies.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PKP2. Recombinant protein control fragment (Product #RP-106737) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664548 |
Product Specific Information
Immunogen sequence:
NLLTERSTFTD SQLGNADMEM TLERAVSMLE ADHMLPSRIS AAATFIQHEC FQKSEARKRV NQLRGILKLL QLLKVQNEDV QRAVC
Highest antigen sequence identity to orthologs:
- Mouse: 78%
- Rat: 51%
Target Information
Plakophilins (PKP1–4) influence development and link cadherins to cytoskeletal intermediate filaments. They contain armadillo repeat domains and localize to nuclei and desmosomes—cell-cell junctions in stratifying epithelia under mechanical stress.
- PKP1: Increases desmosomal protein content, assembly, and regulates cell migration.
- PKP2: Essential for desmosome assembly, morphogenesis, and heart architecture.
- PKP4: Regulates junctional plaque organization and cadherin function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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