Thermo Fisher Scientific AP2M1 Recombinant Rabbit Monoclonal Antibody (23GB3220)
AP2M1 단백질을 인식하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체입니다. Western blot과 면역세포화학(ICC/IF)에 적합하며, 인간, 생쥐, 랫드 시료에 반응합니다. HEK293F 세포에서 발현된 IgG 형식으로, 친화 크로마토그래피로 정제되었습니다. 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB3220 |
| Immunogen | A synthetic peptide of human AP2M1 (350–400 AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family.
The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping during the acidification of endosomes and lysosomes.
AP2M1 has been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use the AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC.
AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein.
At least two isoforms of AP2M1 are known to exist.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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