Thermo Fisher Scientific B3GNT1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Sheep / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CHO-derived recombinant human beta-1,3-N-acetylglucosaminyltransferase 1/B3GNT1 Asp43-Cys415 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:B3GNT1,uniProtId:O43505-1,ncbiNodeId:9606,antigenRange:43-415,antigenLength:415,antigenImageFileName:PA5-47860_B3GNT1_O43505-1_Sheep.svg,antigenImageFileNamePDP:PA5-47860_B3GNT1_O43505-1_Sheep_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2610270

Product Specific Information

In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) B4GalT1 and rhB3GNT 2 is observed.

Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

Target Information

Beta-1,4-glucuronyltransferase involved in O- mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE, during synthesis of phosphorylated O- mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha- dystroglycan (DAG1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.