Thermo Fisher Scientific Phospho-JAK1 (Tyr1022) Polyclonal Antibody
JAK1 Tyr1022 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합. Human, Mouse, Rat 반응성. 고순도 친화 크로마토그래피 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | View publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 1022 (K-E-Y(p)-Y-T) derived from Human JAK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 50% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554225 |
Product Specific Information
A suggested positive control for Western blot is HT29 cells; suggested positive control for IHC is human breast carcinoma.
Target Information
Janus kinase 1 (JAK1) is a protein tyrosine kinase involved in interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli such as interferons and cytokines recruit Stat transcription factors to cytokine receptor-associated JAK1. JAK1 phosphorylates proximal Stat factors, which dimerize and translocate to the nucleus to regulate transcription. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to activate catalytic events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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