Thermo Fisher Scientific MYPT1 Polyclonal Antibody
Rabbit polyclonal antibody targeting MYPT1 for ICC/IF applications. Reacts with human and predicted cross-reactivity to multiple species. High purity via antigen affinity chromatography. Supplied as liquid, unconjugated form for research use only.
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Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human MYPT1 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736186 |
Product Specific Information
Predicted Reactivity: Mouse (91%), Rat (93%), Chicken (85%), Rhesus Monkey (99%), Bovine (96%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Myosin phosphatase target subunit 1 (MYPT1), also known as the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase.
This enzyme regulates the interaction of actin and myosin downstream of the small GTPase Rho.
Active RhoA interacts with the myosin-binding subunit (MBS), modulating phosphorylation of myosin light chain (MLC).
Rho-associated kinase (Rho-kinase), activated by GTP-bound RhoA, phosphorylates MBS and inactivates myosin phosphatase.
Overexpression of RhoA or activated RhoA in NIH 3T3 cells increases phosphorylation of MBS and MLC, indicating that Rho inhibits myosin phosphatase via Rho-kinase.
Several transcript variants encoding different isoforms have been identified for this gene.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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