Thermo Fisher Scientific CD63 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Purity is >95% by SDS-PAGE.

Target Information

CD63 (LAMP-3, lysosome-associated membrane protein-3) is a glycoprotein of the tetraspanin family, found in late endosomes, lysosomes, and secretory vesicles of various cell types. It is also present on the plasma membrane following cell activation and serves as a basophil activation marker. In mast cells, CD63 expression does not require activation. CD63 interacts with integrins, influences phagocytosis and cell migration, and is involved in H/K-ATPase trafficking and ROMK1 channel regulation. It also functions as a T-cell costimulatory molecule and can be used to predict carcinoma prognosis. CD63 is expressed on activated platelets, monocytes, macrophages, and weakly on granulocytes, B, and T cells. It is identical to melanoma-associated antigen ME491 and platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.