Thermo Fisher Scientific TRAF3 Polyclonal Antibody
Human TRAF3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용 제품입니다.
- 카탈로그번호
- PA586563
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 250–300 of Human TRAF3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2803335 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins such as TNF receptor associated factors (TRAFs).
TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40) and the interleukin-1 receptor.
The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization.
Recent molecular cloning studies have identified six TRAFs (TRAF1–TRAF6).
TRAF3, originally named CRAF1, interacts directly with the CD40 cytoplasmic tail through a region similar to the TNF-alpha receptor-associated factors.
TRAF3 binds only a single site containing the sequence PEQET, whereas TRAF1 and TRAF2 can bind to either the PEQET site or an additional downstream domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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