Thermo Fisher Scientific Human ST3GAL6 Synthetic Peptide

Thermo Fisher Scientific Human ST3GAL6 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the carboxy terminus of human ST3GAL6.
PEP-0862 can be used as a blocking peptide with polyclonal antibody PA5-20748.

Target Information

Sialyltransferases catalyze the transfer of sialic acid from cytidine 5-prime monophospho-N-acetylneuraminic acid (CMP-NeuAc) to terminal positions of glycoprotein and glycolipid carbohydrate groups.
Terminal NeuAc residues are key determinants of carbohydrate structures, such as the sialyl-Lewis X determinants, and are widely distributed in many cell types.

Cancer cells often express more heavily sialylated glycans on their surface, correlating with invasiveness. In contrast, expression of ST3GAL6, a member of the sialyltransferase family that sialylates type II lactosamine structures on glycoproteins and glycolipids, is significantly decreased by hypermethylation of the gene in gastrointestinal cancer.
At least three isoforms of ST3GAL6 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.