Thermo Fisher Scientific Human Stem Cell Factor (SCF) Synthetic Peptide

Thermo Fisher Scientific Human Stem Cell Factor (SCF) Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 18 amino acids near the center of human SCF.
PEP-0860 can be used as a blocking peptide with polyclonal antibody PA5-20746.

Target Information

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to receptor homodimerization and activation of signaling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase. SCF expression induces mast cell survival and the release of histamine, pro-inflammatory cytokines, and chemokines. Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting therapeutic potential in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.