Thermo Fisher Scientific Human Stem Cell Factor (SCF) Synthetic Peptide
인간 SCF 중심부 18개 아미노산 서열 기반 합성 펩타이드로, 항체 PA5-20746의 블로킹 펩타이드로 사용 가능. 200 µg/mL 농도의 액상 형태로 제공되며, PBS(pH 7.2, 0.1% BSA) 용액에 보존. 연구용으로만 사용 가능.
- 카탈로그번호
- PEP0860
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human Stem Cell Factor (SCF) Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the center of human SCF.
PEP-0860 can be used as a blocking peptide with polyclonal antibody PA5-20746.
Target Information
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to receptor homodimerization and activation of signaling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase. SCF expression induces mast cell survival and the release of histamine, pro-inflammatory cytokines, and chemokines. Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting therapeutic potential in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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