Thermo Fisher Scientific Sertad1 Polyclonal Antibody
Sertad1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC, ELISA 등 다양한 실험에 적용 가능. 고순도 Protein A 정제, 1 mg/mL 농도, -20°C 보관. 인간, 마우스, 랫트 반응성.
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Thermo Fisher Scientific Sertad1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Sertad1 (amino acids 1–42) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), is a transcriptional regulator that integrates signals from transcription factors.
It acts at E2F-responsive promoters, interacting with PHD- and bromodomains of proteins such as TIF1 and DP-1, transmitting signals to promoters and stimulating transcriptional activity.
SEI-1 forms a multiprotein complex with E2F-1 and DP-1, expressed variably throughout the cell cycle, regulating progression via promoter control during G1 and S phases.
Additionally, SEI-1 modulates cyclin D-Cdk4 complex activity, making it resistant to p16 inhibition. Overexpression is associated with squamous cell carcinoma development in head and neck tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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