Thermo Fisher Scientific RIP2 Polyclonal Antibody
RIP2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western blot과 Immunocytochemistry에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. NF-κB 신호전달 연구에 유용합니다.
- 카탈로그번호
- PA519905
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to amino acids near the amino terminus of human RICK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157005 |
Product Specific Information
- In Western blot applications, this antibody detects a band at approximately 60 kDa.
- Suggested positive control: A431 cell lysate.
- PA5-19905 can be used with blocking peptide PEP-0031.
Target Information
RIPK2 is a serine/threonine kinase involved in cell activation, proliferation, differentiation, and apoptosis. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize, and recruit RIPK2 through CARD-CARD domains. RIPK2 contributes to tyrosine phosphorylation of ARHGEF2 via Src kinase, leading to NF-κB activation. Once recruited, RIPK2 autophosphorylates and undergoes Lys-63-linked polyubiquitination by E3 ligases XIAP, BIRC2, and BIRC3. This modification facilitates MAP3K7/TAK1 recruitment to IKBKG/NEMO, inducing NF-κB activation and transcription of genes related to immune response and apoptosis. RIPK2 also promotes BCL10 phosphorylation during T-cell receptor engagement.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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