Thermo Fisher Scientific ARC Polyclonal Antibody
ARC 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC에 적합. Human 시료 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 2–8°C 보관, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to amino acids 191–208 of human ARC |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154386 |
Product Specific Information
In Western blot applications, this antibody detects a band at approximately 25 kDa.
A suggested positive control is HeLa cell lysate.
PA5-19906 can be used with blocking peptide PEP-0032.
Target Information
ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms:
- Isoform 1: Involved in RNA splicing.
- Isoform 2: Functions as an apoptosis repressor that blocks multiple modes of cell death.
ARC inhibits extrinsic apoptotic pathways by:
- Interacting with FAS and FADD upon FAS activation, blocking death-inducing signaling complex (DISC) assembly.
- Interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting soluble CASP8 available for DISC-mediated activation.
ARC also inhibits intrinsic apoptotic pathways in response to various stresses through interactions with BAX, resulting in BAX inactivation and prevention of mitochondrial dysfunction and release of pro-apoptotic factors.
Mutations affecting the gene can result in myoclonus, familial cortical.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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