Thermo Fisher Scientific ALK Monoclonal Antibody (OTI1E8), TrueMAB
Human ALK 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, Western blot에 최적화된 TrueMAB 제품입니다. 높은 특이성과 재현성을 제공하며, 뇌 발달 및 암 관련 연구에 적합합니다. 액상 형태로 -20°C에서 안정적으로 보관됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a vital role in brain development. Mutations, rearrangements, and amplifications in the ALK gene have been identified in tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangement is the most common genetic alteration, creating a fusion gene between ALK and nucleophosmin (NPM). The NPM-ALK fusion protein is oncogenic. ALK encodes a receptor tyrosine kinase with transmembrane and extracellular domains, absent in the NPM-ALK product, and shows high sequence similarity to LTK.
ALK is essential for neuronal development and function in the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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