Thermo Fisher Scientific CACNA1H, CACNA1G Polyclonal Antibody
CACNA1H 및 CACNA1G 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot과 IHC에 사용 가능하며, 사람, 생쥐, 랫드 반응성. 동결건조 형태로 제공되며, 장기 보관 시 -20°C 권장. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 400–450 of human CACNA1G conjugated to blue carrier protein was used as the antigen. The antigen shares 95% identity with corresponding sequences in rat and mouse. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: CACNA1H and CACNA1G.
Target Information
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and participate in various calcium-dependent processes including muscle contraction, neurotransmitter release, gene expression, cell motility, division, and death.
The alpha-1G isoform gives rise to T-type calcium currents, belonging to the low-voltage activated (LVA) group, and is strongly blocked by mibefradil.
T-type channels open at negative potentials and show voltage-dependent inactivation. They serve pacemaking functions in neurons and cardiac nodal cells, supporting calcium signaling in secretory and vascular smooth muscle cells.
These channels are involved in neuronal firing pattern modulation and cell growth regulation.
There are 2 isoforms of CACNA1H and 14 isoforms of CACNA1G produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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