Thermo Fisher Scientific HBP1 Polyclonal Antibody
HBP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific HBP1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HBP1 (Accession O60381), corresponding to amino acid residues K355–S405 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818140 |
Product Specific Information
Antibody detects endogenous levels of total HBP1.
Target Information
The HMG-box protein-1 (HBP1) is a member of the HMG family of transcription factors, characterized by the presence of a conserved high mobility group (HMG) 1 box that mediates DNA binding.
HBP1 binds to tumor suppressor proteins Rb and p130 and initiates cell cycle arrest. Terminal cell differentiation requires this initial cell cycle arrest followed by expression of tissue-specific marker genes.
Continued HBP1 activity suppresses tissue-specific gene expression by associating with MyoD proteins. In muscle cell differentiation, MyoD family transcription factors (Myf5, MyoD, myogenein) induce expression of cell-type specific proteins and contribute to phenotype development.
The progression of terminal differentiation depends on decreased HBP1 activity and activation of MyoD-induced gene transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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