Thermo Fisher Scientific MED14 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total MED14.

Target Information

The activation of gene transcription is a multistep process triggered by factors recognizing transcriptional enhancer sites in DNA. These factors cooperate with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus.
The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1.
It also forms part of other multisubunit complexes such as thyroid hormone receptor-associated proteins that interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
This protein contains a bipartite nuclear localization signal and is known to escape chromosome X-inactivation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.