Thermo Fisher Scientific C5AR1 Monoclonal Antibody (10/92)
Thermo Fisher Scientific의 C5AR1 Monoclonal Antibody (Clone 10/92)은 mouse CD88(C5aR1)을 인식하는 rat IgG2a 항체입니다. Flow cytometry, IHC, WB 등 다양한 응용에 적합하며, Protein G로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | – | View 2 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | – |
| Immunocytochemistry (ICC/IF) | Assay-dependent | – |
| Flow Cytometry (Flow) | 1:50–1:100 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 10/92 |
| Immunogen | RBL-2H3 transfected cells expressing murine C5aR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_929568 |
Additional Formats:
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
Rat anti-Mouse CD88 antibody, clone 10/92, recognizes murine CD88, a 45 kDa G-protein coupled cell surface receptor, also known as C5aR.
Target Information
CD88 (C5aR1) is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known.
C5AR1 has been implicated in asthma and is expressed in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract.
CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release, and superoxide anion production. It is also a component of the classical complement cascade and may be involved in tissue injury associated with ischemia or sepsis.
Diseases associated with CD88 include:
- Mannose-Binding Lectin Deficiency
- Systemic Lupus Erythematosus
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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