Thermo Fisher Scientific KDM5A Polyclonal Antibody
KDM5A 단백질을 검출하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. Western blot 및 Immunohistochemistry에 사용 가능하며, 인간 및 생쥐 시료에 반응합니다. 항원 친화 크로마토그래피로 정제된 고품질 항체로 연구용에 적합합니다.
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Thermo Fisher Scientific KDM5A Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:300 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human lysine (K)-specific demethylase 5A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636193 |
Product Specific Information
This antibody detects endogenous levels of total KDM5A protein.
Target Information
UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance.
The protein is one of two functional homologs to yeast Upf3p. It binds to mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein.
It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions.
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance.
The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD).
When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons.
This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein.
It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions.
This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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