Thermo Fisher Scientific PCBP4 Polyclonal Antibody
Human PCBP4 단백질을 인식하는 Goat Polyclonal 항체로, Western blot에 적합합니다. 합성 펩타이드(aa 390-403)를 면역원으로 사용하였으며, 0.5 mg/mL 농도의 액상 형태입니다. 다양한 종에서 교차 반응이 예측되며, 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (NGSKKAERQKFSPY) corresponding to the C-terminus amino acids of PCBP4 (aa 390–403) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_10986039 |
Product Specific Information
- This antibody is predicted to react with canine, mouse, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
MCG10 (also known as PCBP4) is a member of the KH-domain RNA-binding protein family, also referred to as alpha-CPs, which bind to RNA with specificity for C-rich pyrimidine regions. These proteins play important roles in post-transcriptional regulation and show different cellular distributions.
MCG10 is induced by p53 and DNA damage via two p53-responsive promoter elements. Overexpression in transfected cells results in suppression of cell proliferation through apoptosis induction and G2-M cell cycle arrest. Decreased expression of specific isoforms has been observed in various lung cancers, suggesting a potential tumor suppressor role. Multiple alternatively spliced isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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