Thermo Fisher Scientific EDN3 Monoclonal Antibody (2A6-2A4)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 0.3 ng/mL

Immunoprecipitation (IP)

• Tested Dilution: 1–5 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MEPGLWLLFG LTVTSAAGFV PCSQSGDAGR RGVSQAPTAA RSEGDCEETV AGPGEETVAG PGEGTVAPTA LQGPSPGSPG QEQAAEGAPE HHRSRRCTCF TYKDKECVYY CHLDIIWINT PEQTVPYGLS NYRGSFRGKR SAGPLPGNLQ LSHRPHLRCA CVGRYDKACL HFCTQTLDVS SNSRTAEKTD KEEEGKVEVK DQQSKQALDL HHPKLMPGSG LALAPSTCPR CLFQEGAP

Target Information

The protein encoded by this gene belongs to the endothelin family, which includes endothelium-derived vasoactive peptides with diverse biological functions.
The active form of EDN3 is a 21 amino acid peptide processed from the precursor protein and serves as a ligand for endothelin receptor type B (EDNRB).
This interaction is critical for the development of neural crest-derived cell lineages such as melanocytes and enteric neurons.
Mutations in EDN3 and EDNRB have been linked to Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), both congenital disorders involving neural crest-derived cells.
Four alternatively spliced transcript variants encoding three distinct isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.