Thermo Fisher Scientific GABRA4 Polyclonal Antibody
Thermo Fisher Scientific의 GABRA4 Polyclonal Antibody는 인간 GABRA4 단백질을 인식하는 염소 유래 IgG 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 합성 펩타이드 기반 항원으로 제작되었으며, 고순도 정제 및 안정적 액상 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (EKAKRKTSKPPQE) corresponding to internal amino acids of GABRA4 (aa 349–362) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10977154 |
Product Specific Information
- This antibody is predicted to react with bovine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain, acting at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines.
At least 16 distinct subunits of GABA-A receptors have been identified.
The GABRA4 gene encodes the alpha-4 subunit, which has been implicated in autism susceptibility through interaction with the gamma-aminobutyric acid receptor beta-1 subunit.
Alternatively spliced transcript variants encoding different isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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