Thermo Fisher Scientific RRAD Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Detects endogenous RRAD protein at a molecular weight of approximately 33 kDa.
• Purity >95% by SDS-PAGE.

Target Information

The Ras-encoded family of proteins bind GDP and GTP with high affinity and exhibit low intrinsic GTPase activity, which increases over 100-fold upon interaction with cytosolic GTPase activating protein (GAP).
Ras family members include H-Ras, K-Ras, N-Ras, M-Ras, R-Ras, ERas, Rheb, TC21, RASL11B, and Rad (Ras associated with diabetes) GTPase.

Rad GTPase is a GTP-binding protein similar to Ras but with unique characteristics. Unlike other small GTPases, Rad GTPase lacks typical prenylation motifs at its C-terminus. It binds calmodulin, inhibits vascular lesion formation, has low intrinsic GTPase activity, and cannot be stimulated by known GAP molecules. Rad GTPase is expressed in skeletal muscle, cardiac muscle, and lung tissues, and is overexpressed in skeletal muscle of individuals with type II diabetes.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.