Thermo Fisher Scientific Interferon gamma (IFNG) Monoclonal Antibody (IFNG/9012)
인간 IFN-γ에 특이적인 마우스 단클론 항체로, 파라핀 포매 조직의 면역조직화학(IHC-P)에 적합합니다. 단백질 A/G로 정제된 액상형 제품이며, 4°C에서 보관합니다. 세포 내 및 세포 표면 IFN-γ 검출에 유용합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC-P)
Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IFNG/9012 |
| Immunogen | Recombinant fragment (around aa1–166) of human IFNG protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human renal or testicular carcinoma
- Cellular Location: Cytoplasm, Cell surface
Target Information
Interferon gamma (IFN-γ, Type II interferon) is a macrophage activation factor and immune interferon produced mainly by T-lymphocytes and natural killer cells in response to antigens and cytokines.
It is a dimeric glycoprotein (~45 kDa) composed of two 146 amino acid subunits, appearing as 25, 20, and minor 15.5 kDa bands on SDS-PAGE due to differential glycosylation.
Human IFN-γ shows species specificity and does not cross-react with mouse IFN-γ.
Functions include:
- Antiviral and tumor antiproliferative activity
- Induction of MHC class I and II
- Macrophage activation
- Enhanced immunoglobulin secretion by B lymphocytes
IFN-γ acts through IFN-γ receptor I and II, activating the JAK-STAT pathway.
It shares ~40% sequence homology with mouse IFN-γ and is regulated by IL2, FGF basic, EGF (upregulated) and vitamin D3 or DMN (downregulated).
Mutations in the IFN-γ gene are associated with aplastic anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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