Thermo Fisher Scientific Lass5 Polyclonal Antibody
Thermo Fisher Scientific의 Lass5 Polyclonal Antibody는 Human, Mouse, Rat에 반응하는 Rabbit IgG 항체입니다. Western blot 및 IHC에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 세라마이드 합성 관련 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 20 µg/mL | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide near the carboxy terminus of the human LASS5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153517 |
Product Specific Information
- A suggested positive control is SK-N-SH cell lysate.
- PA5-20569 can be used with blocking peptide PEP-0689.
Target Information
The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family (LASS1–6) have been characterized and are involved in ceramide synthesis during cell growth regulation and cancer differentiation.
LASS5 (also called Trh4) is a 392 amino acid endoplasmic reticulum multi-pass membrane protein functioning as a dihydro-ceramide synthase. It is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and contributes to the synthesis of C14, C16, and C18-ceramide.
LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially corrects growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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