Thermo Fisher Scientific DNAL1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• A suggested positive control is NIH-3T3 cell lysate.
• PA5-20573 can be used with blocking peptide PEP-0693.

Target Information

DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterologous disorder characterized by chronic infections of the upper and lower airways that often lead to permanent lung damage, randomization of left/right body symmetry, and reduced fertility.
DNAL1 is expressed solely in tissues carrying motile cilia or flagella and interacts with DNAH5, a protein that when mutated results in PCD. It is suggested that DNAL1 serves a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia.
DNAL1 has also been identified as an HIV dependency factor (HDF), suggesting it may be an important drug target in HIV treatment. At least two isoforms of DNAL1 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.