Thermo Fisher Scientific DNAL1 Polyclonal Antibody
DNAL1 단백질을 검출하기 위한 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합합니다. Human, Mouse, Rat 시료에서 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 1 mg/mL 농도의 액상 형태로 제공되며, 연구용으로만 사용됩니다.
- 카탈로그번호
- PA520573
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific DNAL1 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide from near the carboxy terminus of human DNAL1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months; for long-term storage store at -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11151959 |
Product Specific Information
- A suggested positive control is NIH-3T3 cell lysate.
- PA5-20573 can be used with blocking peptide PEP-0693.
Target Information
DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterologous disorder characterized by chronic infections of the upper and lower airways that often lead to permanent lung damage, randomization of left/right body symmetry, and reduced fertility.
DNAL1 is expressed solely in tissues carrying motile cilia or flagella and interacts with DNAH5, a protein that when mutated results in PCD. It is suggested that DNAL1 serves a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia.
DNAL1 has also been identified as an HIV dependency factor (HDF), suggesting it may be an important drug target in HIV treatment. At least two isoforms of DNAL1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.