Thermo Fisher Scientific NBS1 Polyclonal Antibody
NBS1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, ICC/IF, ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 고순도 Affinity Chromatography 정제 제품입니다. 세포핵 및 염색체 관련 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 650–750 of human NBS1/NBN (NP_0024762) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.43 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914698 |
Product Specific Information
- Positive test controls: Jurkat, HeLa, MCF7, Mouse heart, Rat kidney
- Subcellular localization: Chromosome, Nucleus, PML body, Telomere
- Immunogen sequence:
LPKKLLLTEF RSLVIKNSTS RNPSGINDDY GQLKNFKKFK KVTYPGAGKL PHIIGGSDLI AHHARKNTEL EEWLRQEMEV QNQHAKEESL ADDLFRYNPY L
Target Information
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This complex is associated with Nijmegen breakage syndrome, an autosomal recessive disorder characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity. It provides a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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