Thermo Fisher Scientific PDXK Monoclonal Antibody (OTI3G2), TrueMAB
인간 PDXK 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot, IHC, Flow cytometry에 적합합니다. 고순도 친화 크로마토그래피 정제, 액상 형태이며 안정적인 PBS/BSA/glycerol 버퍼에 보관됩니다. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
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Thermo Fisher Scientific PDXK Monoclonal Antibody (OTI3G2), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G2 |
| Immunogen | Full length human recombinant protein of human PDXK produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.45 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA reveals pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript is expressed in all tissues tested. The expression of PDXK shows circadian oscillations. In mice, Pdxk expression in liver and brain is regulated by the 3 PAR bZIP transcription factors (Dbp, Hlf, and Tef), which also show circadian oscillations in expression. Mice lacking all 3 factors exhibit decreased levels of brain PLP, serotonin, and dopamine, and are highly susceptible to spontaneous and audiogenic epilepsies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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