Thermo Fisher Scientific AP2M1 Monoclonal Antibody (OTI 2F11), TrueMAB
AP2M1 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western Blot, IHC, Flow Cytometry에 적합. 인간, 개, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태, 안정적 PBS/BSA/glycerol 버퍼 보존. 연구용 전용 제품.
- 카탈로그번호
- TA503021
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI 2F11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 97–383 of human AP2M1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.98 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family.
The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes.
AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use the AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC.
AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein.
At least two isoforms of AP2M1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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