Thermo Fisher Scientific SOCS3 Monoclonal Antibody (OTI6C2), TrueMAB
Human SOCS3 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, Western blot, ICC/IF, Flow cytometry에 사용 가능. 고순도 친화 크로마토그래피 정제, 안정적 액상 형태로 -20°C 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6C2 |
| Immunogen | Full length human recombinant protein of human SOCS3 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). Eight members of the SOCS family have been recognized: SOCS-1, SOCS-2, SOCS-3, SOCS-4, SOCS-5, SOCS-6, SOCS-7, and CIS.
Structurally, SOCS proteins consist of:
- N-terminal region of variable length and amino acid composition
- Central SH2 domain
- C-terminal SOCS box motif
SOCS proteins form part of a classical negative feedback loop regulating cytokine signal transduction through a STAT-induced transcriptional mechanism. Transcription of SOCS genes occurs rapidly in response to cytokines, and once produced, SOCS proteins inhibit signaling in various ways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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