Thermo Fisher Scientific Phospho-STAT6 (Tyr641) Monoclonal Antibody (J.187.3)
STAT6 단백질의 Tyr641 인산화를 인식하는 Rabbit Monoclonal 항체. Western blot 및 Immunocytochemistry에 적합. 인간 시료 반응성. 교차반응 없음. 액상 형태로 제공되며 -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | J.187.3 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr641 of human STAT6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 103 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10986009 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with the corresponding phospho-tyrosine residues of other Stat proteins.
Target Information
STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL-13. Mice lacking STAT6 (Stat6-/-) show deficiencies in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation.
STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta.
STAT6 is critically involved in Th2 immune response and is crucial for IL-4-mediated biological responses, existing naturally in two isoforms: STAT6a and STAT6c.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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