Thermo Fisher Scientific Human Gemin 2 Synthetic Peptide
인간 SIP1 단백질의 카복시 말단 19개 아미노산 서열에 해당하는 합성 펩타이드입니다. 항체 차단 실험용으로 사용 가능하며, PBS 완충액에 0.1% BSA와 0.02% sodium azide가 포함되어 있습니다. -20°C에서 보관하며 연구용으로만 사용됩니다.
- 카탈로그번호
- PEP1092
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 19 amino acids near the carboxy terminus of human SIP1.
PEP-1092 can be used as a blocking peptide with polyclonal antibody PA5-20978.
Target Information
SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with the SMN and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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