Thermo Fisher Scientific Human TCTN1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the amino terminus of human TCTN1.
PEP-1097 can be used as a blocking peptide with polyclonal antibody PA5-20983.

Target Information

TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later developmental stages, TCTN1 may also act as a repressor on the Hh pathway in the anterior and posterior neural tube.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.