Thermo Fisher Scientific LOX Polyclonal Antibody
LOX 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC 등 다양한 응용에 적합합니다. 인간, 마우스, 돼지, 랫트 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포외기질 형성과 암 전이에 관련된 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–4 µg/mL | View 5 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:250 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide between amino acids 200–300 of the human LOX protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_794775 |
Product Specific Information
PA1-16953 is specific for the ~58 kDa LOX protein.
This is a highly glycosylated protein; therefore, additional bands may appear at approximately 32 kDa (non-glycosylated form), 50 kDa, and 58 kDa (glycosylated forms).
Suggested Positive Controls:
- Human and mouse kidney lysate
- Antigen standard for LOX (transient overexpression lysate)
- Human kidney protein
- Mouse kidney protein
Target Information
Lysyl oxidase (LOX) is a copper-containing amine oxidase belonging to a family of enzymes that oxidize primary amine substrates to reactive aldehydes.
It plays a crucial role in the formation and repair of the extracellular matrix.
LOX is multifunctional, involved in developmental regulation, tumor suppression, cell motility, and cellular senescence.
The secreted form of LOX contributes to the invasive properties of hypoxic human cancer cells, making it an important therapeutic target for preventing and treating metastasis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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