Thermo Fisher Scientific GFR alpha-1 Polyclonal Antibody
GFR alpha-1 단백질을 검출하기 위한 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot 및 IHC(Paraffin) 실험에 최적화되어 있으며, 인간·마우스·랫트 시료에 반응합니다. 항원 친화 크로마토그래피로 정제된 액상 항체로, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Located within amino acids 360–410 of human GFR alpha-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_559265 |
Product Specific Information
Recommended positive controls:
- Human Brain Tissue Lysate (GTX27918)
- Human Liver Tissue Lysate
- Human Kidney Tissue Lysate (GTX29995)
- Human Spleen Tissue Lysate (GTX27921)
Target Information
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nervous system. Physiological responses to GDNF require the presence of a glycosylphosphatidylinositol-linked protein, GDNFRalpha, which acts as a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken, and mouse have been cloned. GDNFRalpha, also known as Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1), is referred to as GFR-alpha-1. GFR-alpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Together, GDNF, GFR-alpha, and Ret PTK form a complex that transduces the GDNF signal and mediates its biological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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