Thermo Fisher Scientific F13A1 Monoclonal Antibody (OTI6F5), TrueMAB

Applications and Tested Dilutions

Product Specifications

Target Information

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits serve as plasma carrier molecules. Platelet factor XIII consists only of 2 A subunits, identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules, stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to the alpha chains of fibrin. Factor XIII deficiency can be type I (lack of both A and B subunits) or type II (lack of A subunit only), leading to lifelong bleeding tendency, defective wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.